Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

ABSTRACT:

Objectives

To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.

Design

Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive PCa (that is, not eligible for surveillance according to National Comprehensive Cancer Network guidelines; any of Gleason score ≥7, stage T3-T4, PSA (prostate specific antigen) concentration ≥10 ng/L, nodal metastasis, distant metastasis). The resulting polygenic hazard score is an assessment of individual genetic risk. The final model was applied to an independent da

SUBMITTER: Seibert TM 

PROVIDER: S-EPMC5759091 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature