Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis.

ABSTRACT:

Objective

Rheumatoid arthritis is an inflammatory joint disease in which synovial iron deposition has been described. Transferrin receptor 2 (Tfr2) represents a critical regulator of systemic iron levels. Loss of Tfr2 function in humans and mice results in iron overload. As iron contributes to inflammatory processes, we investigated whether Tfr2-deletion affects the pathogenesis of inflammatory arthritis in an iron-dependent manner.

Methods

Using a global and conditional genetic disruption of Tfr2, we assessed the relevance of Tfr2 in K/BxN serum-transfer arthritis (STA) and macrophage polarization.

Results

Male Tfr2^-/- mice subjected to STA developed pronounced joint swelling, and bone erosion as compared to Tfr2^+/+ littermate-controls (P < 0.01

SUBMITTER: Ledesma-Colunga MG 

PROVIDER: S-EPMC9932570 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature