Role of genetic testing in young patients with idiopathic atrioventricular conduction disease.

ABSTRACT:

Aims

To investigate the role of genetic testing in patients with idiopathic atrioventricular conduction disease requiring pacemaker (PM) implantation before the age of 50 years.

Methods and results

All consecutive PM implantations in Southern Switzerland between 2010 and 2019 were evaluated. Inclusion criteria were: (i) age at the time of PM implantation: < 50 years; (ii) atrioventricular block (AVB) of unknown aetiology. Study population was investigated by ajmaline challenge and echocardiographic assessment over time. Genetic testing was performed using next-generation sequencing panel, containing 174 genes associated to inherited cardiac diseases, and Sanger sequencing confirmation of suspected variants with clinical implication. Of 2510 patients who underwent PM implanta

SUBMITTER: Auricchio A 

PROVIDER: S-EPMC9934995 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature