CBS-H₂S axis preserves the intestinal barrier function by inhibiting COX-2 through sulfhydrating human antigen R in colitis.

ABSTRACT:

Introduction

Lipopolysaccharide (LPS) causes lesions of the epithelial barrier, which allows translocation of pathogens from the intestinal lumen to the host's circulation. Hydrogen sulfide (H₂S) regulates multiple physiological and pathological processes in colonic epithelial tissue, and CBS-H₂S axis involved in multiple gastrointestinal disorder. However, the mechanism underlying the effect of the CBS-H₂S axis on the intestinal and systemic inflammation in colitis remains to be illustrated.

Objectives

To investigate the effect of CBS-H₂S axis on the intestinal and systematic inflammation related injuries in LPS induced colitis and the underlying mechanisms.

Methods

Wild type and CBS^-/+ mice were used to evaluate

SUBMITTER: Guo S 

PROVIDER: S-EPMC9936422 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature