The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8⁺ T cell differentiation and function.

ABSTRACT: The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of CD4⁺ T cells; however, its cell-intrinsic role in CD8⁺ T cells remains elusive. Herein we show that Ahr acts as a promoter of resident memory CD8⁺ T cell (T_RM) differentiation and function. Genetic ablation of Ahr in mouse CD8⁺ T cells leads to increased CD127^-KLRG1⁺ short-lived effector cells and CD44⁺CD62L⁺ T central memory cells but reduced granzyme-B-producing CD69⁺CD103⁺ T_RM cells. Genome-wide analyses reveal that Ahr suppresses the circulating while promoting the resident memory core gene program. A tumor resident polyfunctional CD8⁺ T cell population, revealed b

SUBMITTER: Dean JW 

PROVIDER: S-EPMC9940759 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature