Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms.

ABSTRACT:

Background

Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. While surgical resection of IPMN-related advanced neoplasia, i.e., IPMN-related high-grade dysplasia or PC, is an essential early PC detection strategy, resection is not recommended for IPMN-low-grade dysplasia (LGD) due to minimal risk of carcinogenesis, and significant procedural risks. Based on their promising results in prior validation studies targeting early detection of classical PC, DNA hypermethylation-based markers may serve as a biomarker for malignant risk stratification of IPMNs. This study investigates our DNA methylation-based PC biomarker panel (ADAMTS1,

SUBMITTER: Chhoda A 

PROVIDER: S-EPMC9942382 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature