Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse.

ABSTRACT: Several lines of evidence suggest that the presence of the Y chromosome influences DNA methylation of autosomal loci. To better understand the impact of the Y chromosome on autosomal DNA methylation patterns and its contribution to sex bias in methylation, we identified Y chromosome dependent differentially methylated regions (yDMRs) using whole-genome bisulfite sequencing methylation data from livers of mice with different combinations of sex-chromosome complement and gonadal sex. Nearly 90% of the autosomal yDMRs mapped to transposable elements (TEs) and most of them had lower methylation in XY compared to XX or XO mice. Follow-up analyses of four reporter autosomal yDMRs showed that Y-dependent methylation levels were consistent across most somatic tissues but varied in strains with dif

SUBMITTER: Batdorj E 

PROVIDER: S-EPMC9947081 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature