Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

ABSTRACT:

Background

COVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathophysiology of COVID-19 and sepsis, we studied their plasma proteome profiles to delineate similarities from specific features.

Methods

We measured 276 plasma proteins involved in Inflammation, organ damage, immune response and coagulation in healthy controls, COVID-19 patients during acute and convalescence phase, and sepsis patients; the latter included (i) community-acquired pneumonia (CAP) caused by Influenza, (ii) bacterial CAP, (iii) non-pneumonia sepsis, and (iv) septic shock patients.

Results

We identified a core response to i

SUBMITTER: Palma Medina LM 

PROVIDER: S-EPMC9950694 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature