Unaltered T cell responses to common antigens in individuals with Parkinson's disease.

ABSTRACT:

Background and objectives

Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).

Methods

Peripheral blood mononuclear cells (PBMCs) from 20 PD patients and 19 age-matched HCs were screened. Antigen specific T cell responses were measured by flow cytometry using a combination of the activation induced marker (AIM) assay and intracellular cytokine staining.

Results

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SUBMITTER: Williams GP 

PROVIDER: S-EPMC9950758 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature