Dataset Information

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

ABSTRACT:

Background/objectives

Admixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely underrepresented in genomic studies. Here, we study the genetic architecture of BMI in children, young adults, and elderly individuals from the admixed population of Brazil.

Subjects/methods

Leveraging admixture in Brazilians, whose chromosomes are mosaics of fragments of Native American, European, and African origins, we used genome-wide data to perform admixture mapping/fine-mapping of body mass index (BMI) in three Brazilian population-based cohorts from Northeast (Salvador), Southeast (Bambuí), and South (Pelotas).

Results

We found significant associations with African-associated alleles in children from Salvador (PALD1 and ZMIZ1 genes), and in young adults from Pelotas (NOD2 and MTUS2 genes). More importantly, in Pelotas, rs114066381, mapped in a potential regulatory region, is significantly associated only in females (p = 2.76e-06). This variant is rare in Europeans but with frequencies of ~3% in West Africa and has a strong female-specific effect (95% CI: 2.32-5.65 kg/m² per each A allele). We confirmed this sex-specific association and replicated its strong effect for an adjusted fat mass index in the same Pelotas cohort, and for BMI in another Brazilian cohort from São Paulo (Southeast Brazil). A meta-analysis confirmed the significant association. Remarkably, we observed that while the frequency of rs114066381-A allele ranges from 0.8 to 2.1% in the studied populations, it attains ~9% among women with morbid obesity from Pelotas, São Paulo, and Bambuí. The effect size of rs114066381 is at least five times higher than the FTO SNPs rs9939609 and rs1558902, already emblematic for their high effects.

Conclusions

We identified six candidate SNPs associated with BMI. rs114066381 stands out for its high effect that was replicated and its high frequency in women with morbid obesity. We demonstrate how admixed populations are a source of new relevant phenotype-associated genetic variants.

SUBMITTER: Scliar MO

PROVIDER: S-EPMC9952852 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

Scliar Marilia O MO Sant'Anna Hanaisa P HP Santolalla Meddly L ML Leal Thiago P TP Araújo Nathalia M NM Alvim Isabela I Borda Victor V Magalhães Wagner C S WCS Gouveia Mateus H MH Lyra Ricardo R Machado Moara M Michelin Lucas L Rodrigues Maíra R MR Araújo Gilderlanio S GS Kehdy Fernanda S G FSG Zolini Camila C Peixoto Sérgio V SV Luizon Marcelo R MR Lobo Francisco F Naslavsky Michel S MS Yamamoto Guilherme L GL Duarte Yeda A O YAO Hansen Matthew E B MEB Norris Shane A SA Gilman Robert H RH Guio Heinner H Hsing Ann W AW Mbulaiteye Sam M SM Mensah James J Dutil Julie J Yeager Meredith M Yeboah Edward E Tishkoff Sarah A SA Choudhury Ananyo A Ramsay Michele M Passos-Bueno Maria Rita MR Zatz Mayana M O Connor Timothy D TD Pereira Alexandre C AC Barreto Mauricio L ML Lima-Costa Maria Fernanda MF Horta Bernardo L BL Tarazona-Santos Eduardo E

International journal of obesity (2005) 20210226 5

<h4>Background/objectives</h4>Admixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely underrepresented in genomic studies. Here, we study the genetic architecture of BMI in children, young adults, and elderly individuals from the admixed population of Brazil.<h4>Subjects/methods</h4>Leveraging admixture in Brazilians, whose chromosomes are mosaics of fragments of Native American, ...[more]

PMID: 33633342

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Dataset Information

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

Background/objectives

Subjects/methods

Results

Conclusions

Publications

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

Similar Datasets

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