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Characterization of NDM-5-Producing Escherichia coli Strains Isolated from Pediatric Patients with Bloodstream Infections in a Chinese Hospital.


ABSTRACT: Escherichia coli (E. coli) bloodstream infections (BSIs) are among the most predominant causes of death in infants and children worldwide. NDM-5 (New Delhi Metallo-lactamase-5) is responsible for one of the main mechanisms of carbapenem resistance in E. coli. To analyze the phenotypic and genomic characteristics of NDM-5-producing E. coli from bloodstream infections (BSIs), a total of 114 E. coli strains was collected from a children's hospital in Jiangsu province, China. Eight blaNDM-5-carrying E. coli strains were identified which were all carbapenem-resistant and carried diverse antimicrobial resistance genes apart from blaNDM-5. They belonged to six distinct sequence types (STs) and serotypes including one each for ST38/O7:H8, ST58/O?:H37, ST131/O25:H4, ST156/O11:H25 and ST361/O9:H30 and three strains are originating from a single clone belonging to ST410/O?:H9. Apart from blaNDM-5, the E. coli strains isolated from BSIs also carried other β-lactamase genes, including blaCMY-2 (n = 4), blaCTX-M-14 (n = 2), blaCTX-M-15 (n = 3), blaCTX-M-65 (n = 1), blaOXA-1 (n = 4) and blaTEM-1B (n = 5). The blaNDM-5 genes were located on three different types of plasmids, which were IncFII/I1 (n = 1), IncX3 (n = 4) and IncFIA/FIB/FII/Q1 (n = 3). The former two types were conjugatively transferable at frequencies of 10-3 and 10-6, respectively. The dissemination of NDM-producing strains, which exhibit resistance to the last-line antibiotics, carbapenems, may increase the muti-antimicrobial resistance burden among E. coli BSIs and further threaten public health.

SUBMITTER: Huang L 

PROVIDER: S-EPMC9956912 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Characterization of NDM-5-Producing <i>Escherichia coli</i> Strains Isolated from Pediatric Patients with Bloodstream Infections in a Chinese Hospital.

Huang Lili L   Hu Hongye H   Xu Chen C   Zhou Mi M   Li Yuanyuan Y   Li Yunbing Y   Wu Shuyan S   Dong Ning N  

Genes 20230218 2


<i>Escherichia coli</i> (<i>E. coli</i>) bloodstream infections (BSIs) are among the most predominant causes of death in infants and children worldwide. NDM-5 (New Delhi Metallo-lactamase-5) is responsible for one of the main mechanisms of carbapenem resistance in <i>E. coli</i>. To analyze the phenotypic and genomic characteristics of NDM-5-producing <i>E. coli</i> from bloodstream infections (BSIs), a total of 114 <i>E. coli</i> strains was collected from a children's hospital in Jiangsu provi  ...[more]

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