Embryotoxicity and Teratogenicity of Steroidal Saponin Isolated from Ophiopholis mirabilis.

ABSTRACT: Benthic invertebrates produce secondary metabolites that serve as defenses against consumers and promote their fitness. To explore the chemical defense in marine benthic echinoderms, the chemical constituents of Ophiopholis mirabilis were investigated. A steroidal monoglycoside, asterosaponin P1, was isolated from O. mirabilis for the first-time using column chromatography. The chemical structure was characterized by spectroscopic and spectrometric methods. The embryotoxicity and teratogenicity of the isolated compound were assessed using the zebrafish embryo assay, a powerful vertebrate animal model system to study mechanisms of toxicity. When applied at high concentrations, asterosaponin P1 causes a significant increase in embryo mortality. A moderate LC₅₀ of ast

SUBMITTER: Xu Q 

PROVIDER: S-EPMC9959855 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature