Antifungal Activity of Isavuconazole and Comparator Agents against Contemporaneous Mucorales Isolates from USA, Europe, and Asia-Pacific.

ABSTRACT: Isavuconazole is the only US FDA-approved antifungal for treating invasive mucormycosis. We evaluated isavuconazole activity against a global collection of Mucorales isolates. Fifty-two isolates were collected during 2017-2020 from hospitals located in the USA, Europe, and the Asia-Pacific. Isolates were identified by MALDI-TOF MS and/or DNA sequencing and susceptibility tested by the broth microdilution method following CLSI guidelines. Isavuconazole (MIC_50/90, 2/>8 mg/L) inhibited 59.6% and 71.2% of all Mucorales isolates at ≤2 mg/L and ≤4 mg/L, respectively. Among comparators, amphotericin B (MIC_50/90, 0.5/1 mg/L) displayed the highest activity, followed by posaconazole (MIC_50/90, 0.5/8 mg/L). Voriconazole (MIC_50/90, >8/>8 mg/L) and the echino

SUBMITTER: Carvalhaes CG 

PROVIDER: S-EPMC9960003 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature