Potential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity.

ABSTRACT: The aim of this study was to investigate the association between selected polymorphisms of nitric oxide synthetase (eNOS) and endothelin-1 (EDN-1) with the occurrence and progression of retinopathy of prematurity (ROP). A prospective study was conducted on 90 preterm infants (44 female), comparing 39 cases with ROP and 51 controls without ROP. Patients who developed ROP were further divided into two subgroups-those with spontaneous regression of the disease and those with ROP requiring treatment. We found that preterm infants with TT genotype eNOS 894G > T had a 12.8-fold higher risk of developing ROP requiring treatment (p = 0.02). Our results showed that allele T of eNOS894G > T polymorphism was significantly more prevalent in ROP patients requiring treatment (p = 0.029). We also investi

SUBMITTER: Choreziak-Michalak A 

PROVIDER: S-EPMC9960447 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature