The Complex Interplay between Nevi and Melanoma: Risk Factors and Precursors.

ABSTRACT: One effort to combat the rising incidence of malignant melanoma is focused on early detection by the clinical and dermoscopic screening of melanocytic nevi. However, the interaction between nevi, which are congenital or acquired benign melanocytic proliferations, and melanoma is still enigmatic. On the one hand, the majority of melanomas are thought to form de novo, as only a third of primary melanomas are associated with a histologically identifiable nevus precursor. On the other hand, an increased number of melanocytic nevi is a strong risk factor for developing melanoma, including melanomas that do not derive from nevi. The formation of nevi is modulated by diverse factors, including pigmentation, genetic risk factors, and environmental sun exposure. While the molecular alterations that

SUBMITTER: Shreberk-Hassidim R 

PROVIDER: S-EPMC9964821 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature