Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery.

ABSTRACT: The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost radiation. Cathepsin-targeted near-infrared fluorescence imaging during BCS could be used to detect residual cancer in the surgical cavity and guide additional resection, thereby preventing tumor-positive resection margins and associated mutilating treatments. The cysteine cathepsins are a family of proteases that play a major role in normal cellular physiology and neoplastic transformation. In breast cancer, the increased enzymatic activity and aberrant localization of many of the cysteine cathepsins drive tumor progression, proliferation, i

SUBMITTER: Linders DGJ 

PROVIDER: S-EPMC9971096 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature