Right Ventricular Architectural Remodeling and Functional Adaptation in Pulmonary Hypertension.

ABSTRACT:

Background

Global indices of right ventricle (RV) function provide limited insights into mechanisms underlying RV remodeling in pulmonary hypertension (PH). While RV myocardial architectural remodeling has been observed in PH, its effect on RV adaptation is poorly understood.

Methods

Hemodynamic assessments were performed in 2 rodent models of PH. RV free wall myoarchitecture was quantified using generalized Q-space imaging and tractography analyses. Computational models were developed to predict RV wall strains. Data from animal studies were analyzed to determine the correlations between hemodynamic measurements, RV strains, and structural measures.

Results

In contrast to the PH rats with severe RV maladaptation, PH rats with mild RV maladaptation showed a decrease i

SUBMITTER: Mendiola EA 

PROVIDER: S-EPMC9974595 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature