Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults.

ABSTRACT:

Introduction

The mechanisms linking motor function to Alzheimer's disease (AD) progression have not been well studied, despite evidence of AD pathology within motor brain regions. Thus, there is a need for new motor measure that is sensitive and specific to AD.

Methods

In a sample of 121 older adults (54 cognitive unimpaired [CU], 35 amnestic Mild Cognitive Impairment [aMCI], and 32 probable mild AD), intrasubject standard deviation (ISD) across six trials of a novel upper-extremity motor task was predicted with volumetric regional gray matter and neuropsychological scores using classification and regression tree (CART) analyses.

Results

Both gray matter and neuropsychological CART models indicated that motor task ISD (our measure of motor learning) was related to cor

SUBMITTER: Malek-Ahmadi M 

PROVIDER: S-EPMC9974847 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature