Is individual perfusion dose-response different than ventilation dose-response for lung cancer patients treated with radiotherapy?

ABSTRACT:

Objective

Current ventilation and perfusion dose-response studies focus on single-modalities (ventilation or perfusion) and perform pulmonary-toxicity assessment related to radiotherapy on a population-based basis. This study aims at quantitative and clinical evaluation of intrapatient differences between ventilation and perfusion dose-responses among lung cancer patients treated with radiotherapy.

Methods

20 patients enrolled on a prospective functional avoidance protocol underwent single photon emission computed tomography-CT ventilation and perfusion scans pre- and post-radiotherapy. Relative changes in pre- to post-treatment ventilation and perfusion in lung regions receiving ≥20 Gy were calculated. In addition, the slopes of the linear fit to the relative ventilation an

SUBMITTER: Forghani F 

PROVIDER: S-EPMC9975372 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature