Gene expression variability across cells and species shapes the relationship between renal resident macrophages and infiltrated macrophages.

ABSTRACT:

Background

Two main subclasses of macrophages are found in almost all solid tissues: embryo-derived resident tissue macrophages and bone marrow-derived infiltrated macrophages. These macrophage subtypes show transcriptional and functional divergence, and the programs that have shaped the evolution of renal macrophages and related signaling pathways remain poorly understood. To clarify these processes, we performed data analysis based on single-cell transcriptional profiling of renal tissue-resident and infiltrated macrophages in human, mouse and rat.

Results

In this study, we (i) characterized the transcriptional divergence among species and (ii) illustrated variability in expression among cells of each subtype and (iii) compared the gene regulation network and (iv) ligand-r

SUBMITTER: Ji X 

PROVIDER: S-EPMC9976410 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature