Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans.

ABSTRACT: During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

SUBMITTER: Waschke L 

PROVIDER: S-EPMC9980052 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature