Dataset Information

Impact of Pulmonary and Sleep Disorders on COVID-19 Infection Severity in a Large Clinical Biobank.

ABSTRACT:

Rationale

Multiple pulmonary, sleep, and other disorders are associated with the severity of Covid-19 infections but may or may not directly affect the etiology of acute Covid-19 infection. Identifying the relative importance of concurrent risk factors may prioritize respiratory disease outbreaks research.

Objectives

To identify associations of common preexisting pulmonary and sleep disease on acute Covid-19 infection severity, investigate the relative contributions of each disease and selected risk factors, identify sex-specific effects, and examine whether additional electronic health record (EHR) information would affect these associations.

Methods

45 pulmonary and 6 sleep diseases were examined in 37,020 patients with Covid-19. We analyzed three outcomes: death; a composite measure of mechanical ventilation and/or ICU admission; and inpatient admission. The relative contribution of pre-infection covariates including other diseases, laboratory tests, clinical procedures, and clinical note terms was calculated using LASSO. Each pulmonary/sleep disease model was then further adjusted for covariates.

Measurements and main results

37 pulmonary/sleep diseases were associated with at least one outcome at Bonferroni significance, 6 of which had increased relative risk in LASSO analyses. Multiple prospectively collected non-pulmonary/sleep diseases, EHR terms and laboratory results attenuated the associations between preexisting disease and Covid-19 infection severity. Adjustment for counts of prior "blood urea nitrogen" phrases in clinical notes attenuated the odds ratio point estimates of 12 pulmonary disease associations with death in women by ≥1.

Conclusions

Pulmonary diseases are commonly associated with Covid-19 infection severity. Associations are partially attenuated by prospectively-collected EHR data, which may aid in risk stratification and physiological studies.

SUBMITTER: Cade BE

PROVIDER: S-EPMC9980259 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Impact of Pulmonary and Sleep Disorders on COVID-19 Infection Severity in a Large Clinical Biobank.

Cade Brian E BE Hassan Syed Moin SM Mullington Janet M JM Karlson Elizabeth W EW Redline Susan S

medRxiv : the preprint server for health sciences 20230223

<h4>Rationale</h4>Multiple pulmonary, sleep, and other disorders are associated with the severity of Covid-19 infections but may or may not directly affect the etiology of acute Covid-19 infection. Identifying the relative importance of concurrent risk factors may prioritize respiratory disease outbreaks research.<h4>Objectives</h4>To identify associations of common preexisting pulmonary and sleep disease on acute Covid-19 infection severity, investigate the relative contributions of each diseas ...[more]

PMID: 36865276

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Dataset Information

Impact of Pulmonary and Sleep Disorders on COVID-19 Infection Severity in a Large Clinical Biobank.

Rationale

Objectives

Methods

Measurements and main results

Conclusions

Publications

Impact of Pulmonary and Sleep Disorders on COVID-19 Infection Severity in a Large Clinical Biobank.

Similar Datasets

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