Thymoquinone ameliorates acrylamide-induced reproductive toxicity in female rats: An experimental study.

ABSTRACT:

Background

Acrylamide (AA) is a carcinogenic compound that causes severe reproductive impairments and represents a high environmental risk factor. Thymoquinone (TQ) has a unique antioxidant activity and has been widely used as a protective agent against various types of toxicity.

Objective

To evaluate the protective effects of TQ against AA-induced reproductive toxicity in female rats.

Materials and methods

In this experimental study, 40 female albino rats (120-150 gr, 8-10 wk) were sorted into 4 groups, (n = 10/each), vehicle group (received a daily oral administration of 0.5 ml saline [9%]); AA group (received a daily oral administration with freshly prepared AA, 20 mg/kg body weight) for 21 days which is less than the lethal dose LD 50 of AA in rats (20 mg/kg body

SUBMITTER: Al-Ghamdi M 

PROVIDER: S-EPMC9982326 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature