Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report.

ABSTRACT:

Background

Fluorouracil-induced leukoencephalopathy is a rare complication and has been reported to present as confusion, oculomotor abnormality, ataxia, and parkinsonism; however, there is no previous report of a presentation mimicking neuroleptic malignant syndrome. Acute cerebellar syndrome may occur, which can be explained by the extremely high accumulation of the drug in the cerebellum. However, presentation mimicking neuroleptic malignant syndrome similar to our case has never been reported.

Case presentation

Here, we describe a 68-year-old Thai male presenting with advanced-stage cecal adenocarcinoma, as well as symptoms and signs indicative of neuroleptic malignant syndrome. He received two doses of intravenous metoclopramide 10 mg 6 hours before his symptoms occurre

SUBMITTER: Hemachudha P 

PROVIDER: S-EPMC9993653 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature