20 million pregnant women with group B streptococcus carriage: consequences, challenges, and opportunities for prevention.

ABSTRACT:

Purpose of review

Intrapartum antibiotic prophylaxis (IAP) is currently the only recommended preventive approach against clinical consequences of maternal Group B Streptococcus (GBS) colonization. In this review, we discuss new findings of total perinatal GBS burden and relative effectiveness of differing targeting of IAP, notably microbiology-based and risk factor-based screening, including potential limitations. Finally, we provide updates on maternal GBS vaccines and their potential cost-effectiveness in disease reduction.

Recent findings

Updated estimates of the burden of GBS related to pregnancy outcomes show (1) early-onset GBS disease incidence and deaths are high in some low- and middle-income countries where IAP has not been implemented and (2) late-onset GBS diseas

SUBMITTER: Paul P 

PROVIDER: S-EPMC9994794 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature