Dataset Information
FIB-SEM of mouse optic nerve of an inducible conditional Mbp knock-out 16 weeks after induction
Ontology highlight
ABSTRACT:
SUBMITTER: Wiebke Möbius
PROVIDER: EMPIAR-10906 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
White matter integrity in mice requires continuous myelin synthesis at the inner tongue.
Nature communications 20220304 1
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure is renewed. Here, we study the integrity of myelinated tracts after experimentally preventing the formation of new myelin in the CNS of adult mice, using an inducible Mbp null allele. Oligodendrocytes survive recombination, continue to express myelin genes, but they fail to maintain compacted myelin ...[more]