Dataset Information
The Anti-Mullerian Hormone prodomain in complex with the growth factor and 6E11 fab
Ontology highlight
ABSTRACT:
SUBMITTER: James A Howard
PROVIDER: EMPIAR-12171 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
A divergent two-domain structure of the anti-Müllerian hormone prodomain.
Proceedings of the National Academy of Sciences of the United States of America 20250113 3
TGFβ family ligands are synthesized as precursors consisting of an N-terminal prodomain and C-terminal growth factor (GF) signaling domain. After proteolytic processing, the prodomain typically remains noncovalently associated with the GF, sometimes forming a high-affinity latent procomplex that requires activation. For the TGFβ family ligand anti-Müllerian hormone (AMH), the prodomain maintains a high-affinity interaction with its GF that does not render it latent. While the prodomain can be di ...[more]