Dataset Information
Convergent and clonotype-specific mutations in the light chain drive affinity maturation of a public antibody targeting a cryptic epitope on S2 of sarbecoviruses
Ontology highlight
ABSTRACT:
SUBMITTER: Goran Bajic
PROVIDER: EMPIAR-13148 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope.
Cell reports 20250812 8
Investigating public antibodies that recognize conserved epitopes is critical for vaccine development. Identifying somatic hypermutations (SHMs) that enhance antigen affinity in these public antibodies is key to guiding vaccine design for better protection against pathogens. We propose that affinity-enhancing SHMs are selectively enriched in public antibody clonotypes, surpassing the background frequency seen in antibodies carrying the same V genes but with different epitope specificities. Using ...[more]
