Dataset Information
Human methemoglobin bound to Staphylococcus aureus hemophore IsdB
Ontology highlight
ABSTRACT:
SUBMITTER: Omar De Bei
PROVIDER: EMPIAR-13213 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction.
Proceedings of the National Academy of Sciences of the United States of America 20220331 14
Iron surface determinant B (IsdB) is a hemoglobin (Hb) receptor essential for hemic iron acquisition by Staphylococcus aureus. Heme transfer to IsdB is possible from oxidized Hb (metHb), but inefficient from Hb either bound to oxygen (oxyHb) or bound to carbon monoxide (HbCO), and encompasses a sequence of structural events that are currently poorly understood. By single-particle cryo-electron microscopy, we determined the structure of two IsdB:Hb complexes, representing key species along the he ...[more]