Dataset Information
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas
Ontology highlight
ABSTRACT:
SUBMITTER: Seth A Darst
PROVIDER: EMPIAR-13448 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas.
Nature microbiology 20251203 1
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains the deadliest human pathogen. Treatment is hampered by drug resistance and the persistence of slow-growing or non-replicating populations. Rifampicin, a cornerstone of first-line therapy, inhibits transcription during promoter escape, but resistance mutations undermine efficacy and drive resistance spread. We revisited the transcription cycle as an antibacterial target by characterizing AAP-SO<sub>2</sub>, an RNA poly ...[more]
