Baker2013 - Cytokine Mediated Inflammation in Rheumatoid Arthritis - Age Dependent

ABSTRACT:

Baker2013 - Cytokine Mediated Inflammation inRheumatoid Arthritis - Age Dependant

This model by Baker M. 2013, describesthe interaction between pro and anti-inflammatory cytokinesignalling in rheumatoid arthritis.

Using two ordinary differential equations, the first model [BIOMD0000000550]analyses bifurcation and describes different pathological states byaltering inflammatory regulation parameters.
The second model [BIOMD0000000549]includes the effect that ageing has on pro-inflammatory signalling,allowing for time-dependant properties and disease progression tobe observed. The author also describes potential dosing forreversal of the disease state.

This model is described in the article:

Mathematical modelling of cytokine-mediated inflammation in rheumatoid arthritis.

Baker M, Denman-Johnson S, Brook BS, Gaywood I, Owen MR.

Math Med Biol 2013 Dec; 30(4): 311-337

Abstract:

Rheumatoid arthritis (RA) is a chronic inflammatory disease preferentially affecting the joints and leading, if untreated, to progressive joint damage and disability. Cytokines, a group of small inducible proteins, which act as intercellular messengers, are key regulators of the inflammation that characterizes RA. They can be classified into pro-inflammatory and anti-inflammatory groups. Numerous cytokines have been implicated in the regulation of RA with complex up and down regulatory interactions. This paper considers a two-variable model for the interactions between pro-inflammatory and anti-inflammatory cytokines, and demonstrates that mathematical modelling may be used to investigate the involvement of cytokines in the disease process. The model displays a range of possible behaviours, such as bistability and oscillations, which are strongly reminiscent of the behaviour of RA e.g. genetic susceptibility and remitting-relapsing disease. We also show that the dose regimen as well as the dose level are important factors in RA treatments.

This model is hosted on BioModels Database and identified by: BIOMD0000000549.

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To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1409250001 | biostudies-other |

SECONDARY ACCESSION(S): 23002057

REPOSITORIES: biostudies-other