Dataset Information
Mouse Iron Distribution - Deficient iron diet (No Tracer)
Ontology highlight
ABSTRACT: Dynamic model of iron distribution in mice. This model includes only normal iron with the parameters that fit the data from Lopes et al. 2010 for mice fed a deficient iron diet. This model does not include the radioiron tracer species. It is appropriate to study the properties in conditions where no tracers are used (for example for steady state analysis).Mouse Iron Distribution Dynamics
ORGANISM(S): Mus musculus
SUBMITTER: Lucian Smith
PROVIDER: MODEL1605030004 | biostudies-other |
SECONDARY ACCESSION(S): 28521769
REPOSITORIES: biostudies-other
Publications
Systems analysis of iron metabolism: the network of iron pools and fluxes.
BMC systems biology 20100813
<h4>Background</h4>Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation i ...[more]
