Dataset Information
Mouse Iron Distribution - Rich and Deficient iron diets (tracer)
Ontology highlight
ABSTRACT: Dynamic model of iron distribution in mice. This model attempts to fit the radioiron tracer data from Lopes et al. 2010 for mice fed iron deficient and rich diets by adjusting the rate of iron intake (vDiet) and the hepcidin synthesis rate (vhepcidin) independently for each experiment. All other parameters are those that provide the best fit for the adequate diet. This model includes the radioiron tracer species. Differences in parameter values between deficient, rich, and adequate diets:Mouse Iron Distribution Dynamics
Diet vDiet vhepcidin Adequate 0.00377422 1.7393e-08 Deficient 0 8.54927e-09 Rich 0.00415624 2.30942e-08
ORGANISM(S): Mus musculus
SUBMITTER: Lucian Smith
PROVIDER: MODEL1903040001 | biostudies-other |
SECONDARY ACCESSION(S): 28521769
REPOSITORIES: biostudies-other
Publications
Systems analysis of iron metabolism: the network of iron pools and fluxes.
BMC systems biology 20100813
<h4>Background</h4>Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation i ...[more]
