Dataset Information
Cardiomyocyte Telomere Damage by ROS without Cell Division
Ontology highlight
ABSTRACT:
SUBMITTER: Carole Proctor
PROVIDER: MODEL1608250001 | biostudies-other |
SECONDARY ACCESSION(S): 30737259
REPOSITORIES: biostudies-other
Publications
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.
The EMBO journal 20190208 5
Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age-related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post-mitotic cardiomyocytes and investigate whether clearance of senescent cells attenuates age-related cardiac dysfunction. During ageing, human and murine cardiomyocytes acquire a senescent-like phenotype characterised by persistent ...[more]
