Dataset Information
Mager2005 - Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition
Ontology highlight
ABSTRACT: This model was developed with the aim of constructing an equilibrium model of the pharmacokinetic behaviour of a drug exhibiting target-mediated drug disposition (TMDD). TMDD involves the inclusion of drug-target interactions within a pharmacokinetic description, something which is usually considered negligible and subsequently excluded. Two approaches were used, one of which involved a quasi-equilibrium method to describe the kinetics of TMDD.
ORGANISM(S): Unknown
SUBMITTER: Lucian Smith
PROVIDER: MODEL1907290001 | biostudies-other |
SECONDARY ACCESSION(S): 16180117
REPOSITORIES: biostudies-other
Publications
Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition.
Pharmaceutical research 20050922 10
<h4>Purpose</h4>The aim of this study is to derive and evaluate an equilibrium model of a previously developed general pharmacokinetic model for drugs exhibiting target-mediated drug disposition (TMDD).<h4>Methods</h4>A quasi-equilibrium solution to the system of ordinary differential equations that describe the kinetics of TMDD was obtained. Computer simulations of the equilibrium model were carried out to generate plasma concentration-time profiles resulting from a large range of intravenous b ...[more]