Dataset Information
Gupta2019 - Restoration of cytosolic calcium inhibits Mycobacterium tuberculosis intracellular growth
Ontology highlight
ABSTRACT: This is a four dimensionsal ordinary differential equation mathematical model that explores the contribution of PI3P during Mycobacterium tuberculosis (Mtb) phagocytosis. The model was built in an effort to understand the mechanisms by which Mtb eliminates phagosome-lysosome fusion during the hosts enactment of anti-microbial pathways.
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1911120004 | biostudies-other |
SECONDARY ACCESSION(S): 31002776
REPOSITORIES: biostudies-other
Publications
Restoration of cytosolic calcium inhibits Mycobacterium tuberculosis intracellular growth: Theoretical evidence and experimental observation.
Journal of theoretical biology 20190416
Mycobacterium tuberculosis (Mtb) is a highly successful intracellular pathogen because of its ability to modulate host's anti-microbial pathways. Phagocytosis acts as the first line of defence against microbial infection. However, Mtb inhibits Phosphatidylinositol 3-phosphate (PI3P) oscillations which is required for phagolysosomal fusion. Here we attempted to understand the mechanisms by which Mtb eliminates phagosome-lysosome fusion. To address this, we built a four dimensional ordinary differ ...[more]
