Dataset Information
Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response
Ontology highlight
ABSTRACT: This is a within-host hepatitis B viral mathematical model for hepatitis B in the acute phase of infection. The model incorporates hepatocytes, hepatitis B virus, immune system cells and cytokine dynamics using a system of ordinary differential equations.
ORGANISM(S): Homo sapiens
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1911280002 | biostudies-other |
SECONDARY ACCESSION(S): 10.1007/s12064-019-00305-2
REPOSITORIES: biostudies-other
Publications
Modeling the immune rheostat of macrophages in the lung in response to infection.
Proceedings of the National Academy of Sciences of the United States of America 20090622 27
In the lung, alternatively activated macrophages (AAM) form the first line of defense against microbial infection. Due to the highly regulated nature of AAM, the lung can be considered as an immunosuppressive organ for respiratory pathogens. However, as infection progresses in the lung, another population of macrophages, known as classically activated macrophages (CAM) enters; these cells are typically activated by IFN-gamma. CAM are far more effective than AAM in clearing the microbial load, pr ...[more]
