Stromal cell subsets modulate T-cell infiltration in early breast cancer

ABSTRACT: Recent studies of the tumour microenvironment have elucidated the heterogeneity of stromal cells, with increasing evidence suggesting that stromal subsets play an important role in regulating anti-tumour immunity in breast cancer. However, the functional diversity of these cells within the tumour immune microenvironment and how they interact with immune cells in a spatial and clinical context remain poorly understood. We performed multiplex immunofluorescence on tumour microarrays from two cohorts consisting of 591 breast cancer patients to assess the abundance and spatial co-localisation of stromal and immune subsets and their correlation with clinicopathological features and patient outcomes. We found that stromal cells were spatially distinct. A perivascular-like subset that was dissemi

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Julia Chen 

PROVIDER: S-BSST3074 | biostudies-other |

REPOSITORIES: biostudies-other