Functional characterization of E- and P-cadherin in invasive breast cancer cells

ABSTRACT: Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood. Methods: To compare the functional role of E-cadherin and P-cadherin in invasive breast cancer, we stably transfected these molecules into the MDA-MB-231 cell line, and investigated their effects on motility, invasion and gene expression regulation. Expression of either E- and P-cadherin significantly increased cell aggregation and induced a switch from fibroblastic to epithelial morphology. Although expression of these cadherins did not completely reverse the mesenchymal phenotype of MDA-MB-231 cells, both E- and P-cadherin decreased fibroblast-like migration

ORGANISM(S): Homo sapiens

SUBMITTER: Moreno-Bueno Gema 

PROVIDER: S-ECPF-GEOD-13362 | biostudies-other |

REPOSITORIES: biostudies-other