Response of A549 cells treated with Aspergillus fumigatus [WT-CF_vs_WT-GC]

ABSTRACT: Response of A549 cells treated with Aspergillus fumigatus germinating conidia (WT-GC) or culture filtrate (WT-CF) for 8h Aspergillus fumigatus is the most commonly encountered mold pathogen of humans, predominantly infecting the respiratory system. Colonization and penetration of the lung alveolar epithelium is a key but poorly understood step in the infection process. This study focused on identifying the transcriptional and cell-signaling responses activated in A549 alveolar carcinoma cells incubated in the presence of A. fumigatus wild-type and ΔPrtT protease-deficient germinating conidia and culture filtrates (CF). Microarray analysis of exposed A549 cells identified distinct classes of genes whose expression is altered in the presence of germinating conidia and CF and suggested the in

ORGANISM(S): Homo sapiens

SUBMITTER: Sharon Haim 

PROVIDER: S-ECPF-GEOD-24983 | biostudies-other |

REPOSITORIES: biostudies-other