Butyrophilin 3A1 binds phosphorylated antigens and stimulates human TCR ?? cells
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ABSTRACT: We used genetic approaches to identify butyrophilin 3A1 (BTN3A1) as the molecule that binds and presents phosphorylated antigens to Vγ9Vδ2 TCR–expressing cells. BTN3A1 represents a novel antigen–presenting molecule for the activation of Vγ9Vδ2 TCR–expressing cells which play important roles in human tumor immunity and host defense. 3 replicates of 4 cell lines (12 samples total) were analysed. Data was RMA normalized, and genes that expressed above the negative control in all 4 cell lines from chromosome 6 considered for further analysis
ORGANISM(S): Homo sapiens
SUBMITTER: chen jinmiao
PROVIDER: S-ECPF-GEOD-37634 | biostudies-other |
REPOSITORIES: biostudies-other
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