Transcription profiling of human ER+ BrC cells with and without estradiol in both cell cultures and xenografts

ABSTRACT: We generated DNA microarray based gene expression profiles from three estrogen receptor a (ERa) positive breast cancer cell lines stimulated by 17ß-estradiol (E2) in vitro over a time course, as well as from MCF-7 cells grown as xenografts in ovariectomized athymic nude mice with E2 supplementation and after its withdrawal. Experiment Overall Design: 8 MCF-7 xenograft profiles (4 with E2,4 without E2), 14 T47D profiles (with E2 treatment in culture from 0 to 24 hr), 10 BT-474 profiles (with E2 treatment from 0 to 24 hr), 12 MCf-7 profiles (with E2 treatment from 0 to 24 hr)

ORGANISM(S): Homo sapiens

SUBMITTER: Creighton CJ 

PROVIDER: S-ECPF-GEOD-3834 | biostudies-other | 2006

REPOSITORIES: biostudies-other