Transcription profiling of primary human breast tumors showing poor clinical prognosis

ABSTRACT: Using microarray analysis, we identified a unique ras superfamily gene, termed RERG (ras-related and estrogen-regulated growth inhibitor), whose expression was decreased or lost in a significant percentage of primary human breast tumors that show a poor clinical prognosis. Importantly, high RERG expression correlated with expression of a set of genes that define a breast tumor subtype that is estrogen receptor-positive and associated with a slow rate of tumor cell proliferation and a favorable prognosis for these cancer patients. RERG mRNA expression was induced rapidly in MCF-7 cells stimulated by beta-estradiol and repressed by tamoxifen treatment. Like Ras, RERG protein exhibited intrinsic GDP/GTP binding and GTP hydrolysis activity. Unlike Ras proteins, RERG lacks a known recognition s

ORGANISM(S): Homo sapiens

SUBMITTER: Finlin BS 

PROVIDER: S-ECPF-SMDB-1443 | biostudies-other | 2001 Nov

REPOSITORIES: biostudies-other