Ontology highlight
ABSTRACT:
SUBMITTER: Bucheli ME
PROVIDER: S-EPMC1150882 | biostudies-other | 2005 Jun
REPOSITORIES: biostudies-other
The EMBO journal 20050519 12
Proper 3' end formation is critical for the production of functional mRNAs. Termination by RNA polymerase II is linked to mRNA cleavage and polyadenylation, but it is less clear whether earlier stages of mRNA production also contribute to transcription termination. We performed a genetic screen to identify mutations that decreased transcriptional readthrough of a defective GAL10 poly(A) terminator. A partial deletion of the GAL10 downstream region leads to transcription through the downstream GA ...[more]