Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC1462322 | biostudies-other | 2002 Nov
REPOSITORIES: biostudies-other
Zhang HaiGuang H Tan Jeff J Reynolds Elaine E Kuebler Daniel D Faulhaber Sally S Tanouye Mark M
Genetics 20021101 3
We report here the characterization of slamdance (sda), a Drosophila melanogaster "bang-sensitive" (BS) paralytic mutant. This mutant exhibits hyperactive behavior and paralysis following a mechanical "bang" or electrical shock. Electrophysiological analyses have shown that this mutant is much more prone to seizure episodes than normal flies because it has a drastically lowered seizure threshold. Through genetic mapping, molecular cloning, and RNA interference, we have demonstrated that the sda ...[more]