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An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data.

ABSTRACT: Affymetrix exon arrays contain probesets intended to target every known and predicted exon in the entire genome, posing significant challenges for high-throughput genome-wide data analysis. X:MAP http://xmap.picr.man.ac.uk, an annotation database, and exonmap http://www.bioconductor.org/packages/2.0/bioc/html/exonmap.html, a BioConductor/R package, are designed to support fine-grained analysis of exon array data. The system supports the application of standard statistical techniques, prior to the use of genome scale annotation to provide gene-, transcript- and exon-level summaries and visualization tools.

SUBMITTER: Okoniewski MJ 

PROVIDER: S-EPMC1929135 | biostudies-other | 2007

REPOSITORIES: biostudies-other

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An annotation infrastructure for the analysis and interpretation of Affymetrix exon array data.

Okoniewski Michał J MJ   Yates Tim T   Dibben Siân S   Miller Crispin J CJ  

Genome biology 20070101 5

Affymetrix exon arrays contain probesets intended to target every known and predicted exon in the entire genome, posing significant challenges for high-throughput genome-wide data analysis. X:MAP http://xmap.picr.man.ac.uk, an annotation database, and exonmap http://www.bioconductor.org/packages/2.0/bioc/html/exonmap.html, a BioConductor/R package, are designed to support fine-grained analysis of exon array data. The system supports the application of standard statistical techniques, prior to th  ...[more]

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