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Caenorhabditis elegans SDF-9 enhances insulin/insulin-like signaling through interaction with DAF-2.

ABSTRACT: SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling.

SUBMITTER: Jensen VL

PROVIDER: S-EPMC2013707 | biostudies-other | 2007 Sep

REPOSITORIES: biostudies-other

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