Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis Elegans
SUBMITTER: Mengqiu Dong
PROVIDER: PXD020440 | iProX | Thu Jun 10 00:00:00 BST 2021
REPOSITORIES: iProX
Nature communications 20210727 1
Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we profile IIS-dependent phosphorylation changes in a large-scale quantitative phosphoproteomic analysis of wild-type and three IIS mutant Caenorhabditis elegans strains. We quantify more than 15,000 phosphosites and find that 476 of these are differentially phosphorylated in the long-lived daf ...[more]