Ontology highlight
ABSTRACT:
SUBMITTER: Chiroli E
PROVIDER: S-EPMC2064206 | biostudies-other | 2007 May
REPOSITORIES: biostudies-other
The Journal of cell biology 20070514 4
Faithful chromosome transmission requires establishment of sister chromatid cohesion during S phase, followed by its removal at anaphase onset. Sister chromatids are tethered together by cohesin, which is displaced from chromosomes through cleavage of its Mcd1 subunit by the separase protease. Separase is in turn inhibited, up to this moment, by securin. Budding yeast cells respond to morphogenetic defects by a transient arrest in G2 with high securin levels and unseparated chromatids. We show t ...[more]