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Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.

ABSTRACT: The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.

SUBMITTER: Hobert O 

PROVIDER: S-EPMC231301 | biostudies-other | 1996 Jun

REPOSITORIES: biostudies-other

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Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.

Hobert O O   Jallal B B   Ullrich A A  

Molecular and cellular biology 19960601 6

The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in t  ...[more]